eTable 4. Risk of PPOU according to presence of risk factors.

	Risk of PPOU (%)
Risk factor	Risk factor not present	Risk factor present	Difference
Sex (male vs. female)	1.19%	1.58%	0.39%
Coagulopathy (no vs. yes)	1.41%	2.33%	0.92%
Chronic pulmonary disease (no vs. yes)	1.33%	1.88%	0.55%
Cardiovascular disease (no vs. yes)	0.62%	2.24%	1.61%
Diabetes (no vs. yes)	1.19%	2.98%	1.79%
Renal disease (no vs. yes)	1.27%	3.82%	2.55%
Depression (no vs. yes)	1.22%	2.18%	0.96%
Anxiety (no vs. yes)	1.42%	1.74%	0.32%
Bipolar disorder (no vs. yes)	1.44%	2.43%	0.99%
Other mood disorder (no vs. yes)	1.44%	2.35%	0.91%
Posttraumatic stress disorder (no vs. yes)	1.45%	1.28%	-0.17%
Alcohol abuse (no vs. yes)	1.39%	3.38%	1.99%
Tobacco abuse (no vs. yes)	1.40%	1.83%	0.43%
Cocaine abuse (no vs. yes)	1.44%	1.68%	0.24%
Other substance abuse (no vs. yes)	1.42%	2.86%	1.44%
Other psychiatric comorbidities (no vs. yes)	1.39%	1.82%	0.43%
Fibromyalgia (no vs. yes)	1.42%	3.41%	1.99%
Migraine (no vs. yes)	1.45%	1.30%	-0.15%
Chronic pain (no vs. yes)	1.17%	3.38%	2.21%
Prescription of non-opioid analgesics (no vs. yes)	0.75%	2.17%	1.41%
Prescription of benzodiazepines (no vs. yes)	1.40%	3.68%	2.28%
Prescription of antidepressants (no vs. yes)	1.06%	3.59%	2.53%

PPOU, Prolonged postoperative opioid use; vs., versus