Table 2.
Association between migraine and ASCVD in the UK biobank
| People without migraine | People with migraine | P value | P FDR | |
|---|---|---|---|---|
| ASCVD | ||||
| No. of cases/total | 23,095/254,051 | 943/11,743 | ||
| Multivariable adjusteda | 1(Reference) | 1.12(1.05,1.20) | <0.001 | <0.001 |
| Multivariable adjusteda+ lifestyle factors | 1(Reference) | 1.12(1.05,1.20) | <0.001 | <0.001 |
| Multivariable adjusteda+ traditional factor control | 1(Reference) | 1.13(1.05,1.20) | <0.001 | <0.001 |
| Model included all covariates | 1(Reference) | 1.12(1.05,1.20) | <0.001 | <0.001 |
| Coronary heart disease | ||||
| No. of cases/total | 11,743/254,051 | 708/11,743 | ||
| Multivariable adjusteda | 1(Reference) | 1.09(1.01,1.18) | 0.021 | 0.023 |
| Multivariable adjusteda+ lifestyle factors | 1(Reference) | 1.09(1.01,1.17) | 0.029 | 0.030 |
| Multivariable adjusteda+ traditional factor control | 1(Reference) | 1.09(1.02,1.18) | 0.019 | 0.020 |
| Model included all covariates | 1(Reference) | 1.09(1.01,1.18) | 0.026 | 0.029 |
| Ischaemic stroke | ||||
| No. of cases/total | 3466/254,051 | 142/11,743 | ||
| Multivariable adjusteda | 1(Reference) | 1.13(0.95,1.34) | 0.162 | 0.199 |
| Multivariable adjusteda+ lifestyle factors | 1(Reference) | 1.13(0.96,1.34) | 0.151 | 0.188 |
| Multivariable adjusteda+ traditional factor control | 1(Reference) | 1.14(0.96,1.34) | 0.141 | 0.188 |
| Model included all covariates | 1(Reference) | 1.14(0.96,1.35) | 0.133 | 0.177 |
| Peripheral artery disease | ||||
| No. of cases/total | 4314/254,051 | 179/11,743 | ||
| Multivariable adjusteda | 1(Reference) | 1.23(1.05,1.42) | 0.008 | 0.011 |
| Multivariable adjusteda+ lifestyle factors | 1(Reference) | 1.23(1.06,1.43) | 0.007 | 0.009 |
| Multivariable adjusteda+ traditional factor control | 1(Reference) | 1.24(1.07,1.44) | 0.005 | 0.008 |
| Model included all covariates | 1(Reference) | 1.25(1.07,1.45) | 0.005 | 0.006 |
Adjusteda for sex, age, race, income level, education, BMI, family history of cardiovascular disease, comorbidities, and lifestyle factors, including physical activity, diet, sleep pattern, and drinking; traditional risk factor control including glycated hemoglobin control, blood pressure control, low-density-lipoprotein cholesterol control, and no current smoking; HR, hazard ratio; CI, confidence interval