Table 3.

Multivariable-adjusted HRs (95% CIs) of migraine for ASCVD by gender and age group

ASCVD	No. of events/total		HR (95% CI)
Women	People without migraine	People with migraine	Model 1	Model 2	Model 3	Model 4
<45	318/19,744	45/1404	1.66 (1.21, 2.28)	1.62 (1.18, 2.23)	1.64 (1.2, 2.26)	1.6 (1.16, 2.2)
P value			0.001	0.003	0.002	0.004
P FDR			0.004	0.009	0.007	0.014
45–55	1570/44,301	136/3399	1.1 (0.92, 1.31)	1.09 (0.91, 1.3)	1.1 (0.92, 1.31)	1.09 (0.92, 1.3)
P value			0.294	0.337	0.284	0.326
P FDR			0.340	0.373	0.360	0.416
55–65	4448/58,336	312/3571	1.14 (1.02, 1.28)	1.14 (1.02, 1.28)	1.15 (1.02, 1.29)	1.15 (1.02, 1.29)
P value			0.022	0.025	0.018	0.020
P FDR			0.027	0.031	0.024	0.027
>65	2118/15,812	114/703	1.28 (1.06, 1.54)	1.28 (1.06, 1.54)	1.27 (1.05, 1.54)	1.27 (1.05, 1.54)
P value			0.011	0.011	0.012	0.012
P FDR			0.021	0.022	0.025	0.028
Men
<45	759/17,316	24/405	1.3 (0.86, 1.95)	1.31 (0.87, 1.97)	1.29 (0.86, 1.94)	1.3 (0.86, 1.95)
P value			0.212	0.198	0.220	0.210
P FDR			0.265	0.250	0.298	0.283
45–55	3047/35,519	84/890	1.09 (0.88, 1.36)	1.1 (0.88, 1.36)	1.11 (0.9, 1.38)	1.11 (0.89, 1.38)
P value			0.414	0.4	0.336	0.339
P FDR			0.414	0.445	0.375	0.410
55–65	7520/48,442	173/1099	1.02 (0.88, 1.18)	1.02 (0.87, 1.18)	1.02 (0.88, 1.19)	1.02 (0.88, 1.19)
P value			0.82	0.829	0.755	0.781
P FDR			0.82	0.829	0.755	0.781
>65	3315/14,581	55/272	0.89 (0.68, 1.16)	0.89 (0.68, 1.16)	0.9 (0.69, 1.17)	0.9 (0.69, 1.17)
P value			0.401	0.397	0.435	0.428
P FDR			0.401	0.419	0.473	0.492

Adjusted^a for sex, age, race, income level, education, BMI, family history of cardiovascular disease, comorbidities, and lifestyle factors, including physical activity, diet, sleep pattern, and drinking; traditional risk factor control including glycated hemoglobin control, blood pressure control, low-density-lipoprotein cholesterol control, and no current smoking; HR, hazard ratio; CI, confidence interval