Table 1.
Mendelian randomization analysis results of antidiabetic drug target genes screened based on glycated hemoglobin (HbA1c)
| Target gene | Method | nSNP | OR | LCI95 | UCI95 | P.val | Q.pval | MR-PRESSO | MR-Egger | FDR |
|---|---|---|---|---|---|---|---|---|---|---|
| SGLT2i | MR Egger | 22 | 0.902 | 0.005 | 151.240 | 0.969 | 0.907 | 0.911 | 0.385 | 0.969 |
| Weighted median | 22 | 0.094 | 0.011 | 0.812 | 0.032 | 0.148 | ||||
| Inverse variance weighted | 22 | 0.099 | 0.021 | 0.463 | 0.003 | 0.907 | 0.030 | |||
| Simple mode | 22 | 0.016 | < 0.001 | 0.703 | 0.044 | 0.520 | ||||
| Weighted mode | 22 | 0.102 | 0.004 | 2.740 | 0.188 | 0.376 | ||||
| GPD1 | MR Egger | 4 | 2.282 | < 0.001 | 1.114E + 09 | 0.943 | 0.997 | 0.969 | 0.626 | 0.969 |
| Weighted median | 4 | 0.011 | < 0.001 | 0.499 | 0.020 | 0.143 | ||||
| Inverse variance weighted | 4 | 0.007 | < 0.001 | 0.204 | 0.004 | 0.954 | 0.030 | |||
| Simple mode | 4 | 0.011 | < 0.001 | 1.921 | 0.186 | 0.520 | ||||
| Weighted mode | 4 | 0.011 | < 0.001 | 1.379 | 0.165 | 0.376 | ||||
| SLC5A1 | MR Egger | 9 | 0.039 | < 0.001 | 3433.101 | 0.593 | 0.304 | 0.388 | 0.971 | 0.969 |
| Weighted median | 9 | 0.007 | < 0.001 | 0.194 | 0.003 | 0.049 | ||||
| Inverse variance weighted | 9 | 0.048 | 0.004 | 0.585 | 0.017 | 0.401 | 0.092 | |||
| Simple mode | 9 | 0.006 | < 0.001 | 1.173 | 0.094 | 0.520 | ||||
| Weighted mode | 9 | 0.007 | < 0.001 | 0.774 | 0.073 | 0.376 |
This table presents the Mendelian randomization (MR) analysis results of antidiabetic drug target genes, which were screened based on their association with HbA1c. The analysis evaluates the potential causal association between these target genes and male infertility. Key statistical metrics provided include the odds ratio (OR) with corresponding 95% confidence intervals (LCI95–UCI95) and p-values (P.val) to assess the significance of the associations. Additionally, the table includes the number of single nucleotide polymorphisms (nSNP) used in each MR method, heterogeneity test results (Q.pval), and sensitivity analyses using MR-PRESSO and MR-Egger methods to detect potential pleiotropy and instrumental variable validity. The false discovery rate (FDR) is also reported to adjust for multiple comparisons and ensure the robustness of the findings. A p-value (P < 0.05) and an FDR < 0.1 indicate a significant causal relationship between the target gene and male infertility