Table 5.
Concordance of the alternative measures of response to MDR-TB treatment compared to MGIT among HIV-Positive participants
| Method | CFM concordance n/N (%) |
FDA concordance n/N (%) |
TBMBLA concordance n/N (%) |
MB7H11S concordance n/N (%) |
||||
|---|---|---|---|---|---|---|---|---|
| Weeks | Pos | Neg | Pos | Neg | Pos | Neg | Pos | Neg |
| W2 | 14/19 (73.7) |
4/5 (100) |
10/19 (52.6) |
5/5 (100) |
8/17 (47.1) |
4/5 (80.0) |
7/19 (36.8) |
5/5 (100) |
| W4 | 8/14 (38.1) |
7/7 (100) |
4/14 (28.6) |
7/7 (100) |
8/13 (61.5) |
3/4 (75.0) |
4/11 (36.4) |
7/7 (100) |
| W6 | 4/9 (44.4) |
9/9 (100) |
2/9 (22.2) |
9/9 (100) |
3/7 (42.9) |
6/9 (66.7) |
1/9 (11.1) |
9/9 (100) |
| W8 | 2/4 (50.0) |
12/13 (92.3) |
2/4 (50.0) |
12/13 (92.3) |
0/2 (0.0) |
7/11 (63.6) |
1/4 (25.0) |
11/11 (100) |
| W12 | -----* | 15/15 (100) |
-----* | 14/14 (100) |
----* | 11/11 (100) |
1/1 (100) |
11/11 (100) |
| W16 | -----* | 17/17 (100) |
----* | 14/14 (100) |
---* | 13/13 (100) |
-----* | 15/15 (100) |
------*: All negative by the test and no false positive, CFM=Concentrated Fluorescent Microscopy, FDA=, TB MBLA– Tuberculosis Molecular Bacterial Load Assay, MGIT= Mycobacterial Growth Indicator Tube, MB7H11S= Middle Brook 7H11 Selective, W=Weeks, Pos = positive, Neg=Negative