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Parameters of the Pop PK/PD Final Model
| Model | Parameters | Values | Units |
|---|---|---|---|
| Covariate model | tvKa | 0.79 | ·h−1 |
| tvV | 3383 | L | |
| tvCl | 58.76 | L·h−1 | |
| tvIC50 | 1.71 | ng/mL | |
| tvE0 | 168 | ||
| tvImax | 31.1 | ||
| dCLdUA | −0.69 | ||
| dCLdeGFR | 0.95 | ||
| stdev0 | 0.06 | ||
| OFV | −2617.95 |
Notes: dCldUA, model-estimated coefficient of UA on CL. dCLdeGFR, model-estimated coefficient of eGFR on CL.
