Table 3.
Loci with Genome-wide Significance for Fissure Integrities
| Location |
Allele |
Left Major
>95% |
Right Major
>95% |
Right Minor
>95% |
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Chr | Marker | Position | Ref | Alt | Alt Fq | OR (95% CI) | P Value | OR (95% CI) | P Value | OR (95% CI) | P Value |
| Non-Hispanic White Patients | |||||||||||
| 12 | rs7310342 | 43222842 | G | A | 0.38 | 1.26 (1.05–1.51) | 2.07 × 10−9 | 1.27 (1.05–1.53) | 1.41 × 10−9 | 1.06 (0.94–1.20) | N.S. |
| 17 | rs7209556 | 48388801 | C | T | 0.46 | 0.81 (0.68–0.96) | 1.42 × 10−8 | 0.93 (0.84–1.03) | N.S. | 0.80 (0.63–1.00) | N.S. |
| 3 | rs2173623 | 55562888 | T | C | 0.43 | 0.81 (0.68–0.96) | 2.39 × 10−8 | 0.84 (0.72–0.99) | 7.75 × 10−6 | 0.87 (0.73–1.04) | N.S. |
| 12 | rs2407284 | 43216289 | G | A | 0.27 | 0.80 (0.66–0.96) | 6.52 × 10−8 | 0.83 (0.69–0.98) | 7.24 × 10−7 | 0.80 (0.63–1.01) | N.S. |
| 17 | rs6504172 | 48330072 | T | C | 0.28 | 0.81 (0.67–0.97) | 2.07 × 10−7 | 0.94 (0.85–1.04) | N.S. | 0.76 (0.59–0.99) | N.S. |
| 5 | rs264866 | 169635918 | C | T | 0.69 | 0.83 (0.70–0.98) | 2.24 × 10−6 | 0.84 (0.71–0.99) | 9.41 × 10−6 | 0.74 (0.57–0.97) | 4.81 × 10−7 |
| 14 | rs4904145 | 83871856 | A | G | 0.31 | 1.00 (0.98–1.03) | N.S. | 0.95 (0.87–1.04) | N.S. | 1.46 (1.06–2.00) | 7.10 × 10−8 |
| African American Patients | |||||||||||
| 12 | rs7310342 | 43222842 | G | A | 0.26 | 1.19 (0.97–1.46) | N.S. | 1.16 (0.97–1.40) | N.S. | 1.05 (0.94–1.18) | N.S. |
| 17 | rs7209556 | 48388801 | C | T | 0.64 | 1.27 (1.00–1.61) | N.S. | 1.03 (0.95–1.12) | N.S. | 1.08 (0.94–1.23) | N.S. |
| 3 | rs2173623 | 55562888 | T | C | 0.52 | 1.18 (0.97–1.42) | N.S. | 1.16 (0.98–1.38) | N.S. | 1.03 (0.95–1.12) | N.S. |
| 12 | rs2407284 | 43216289 | G | A | 0.41 | 0.80 (0.64–1.01) | N.S. | 0.79 (0.63–0.98) | N.S. | 0.89 (0.75–1.05) | N.S. |
| 17 | rs6504172 | 48330072 | T | C | 0.36 | 0.75 (0.57–0.97) | 1.96 × 10−6 | 0.98 (0.92–1.05) | N.S. | 0.92 (0.79–1.06) | N.S. |
| 5 | rs264866 | 169635918 | C | T | 0.57 | 0.71 (0.53–0.94) | 1.14 × 10−8 | 0.83 (0.69–1.01) | N.S. | 0.74 (0.56–0.96) | 1.02 × 10−9 |
| 14 | rs4904145 | 83871856 | A | G | 0.50 | 0.96 (0.87–1.06) | N.S. | 0.97 (0.89–1.05) | N.S. | 1.43 (1.07–1.92) | 2.45 × 10−9 |
Definition of abbreviations: Alt = alternate allele; Alt Fq = alternate allele frequence; Chr = chromosome; CI = confidence interval; N.S. = P > 1 × 10−5; OR = odds ratio; Ref = reference allele.
Data are presented as median. Kruskal-Wallis test was performed to test for statistically significant differences between the groups.
Subjects with fissure integrities <95% were set as cases, and subjects with fissure integrities ⩾95% were set as controls.