Table 3.

Treatment Response to ISZ and Possible ISZ-Attributable Adverse Events

Case No.	Outcome	Causes of Death	Hepatotoxicity	Nephrotoxicity	QT Interval Changes
1	Death	Hematologic malignancy	No	No	No
2	Improvement	NA	No	No	No
3	Death	Infection	No	Yes	No
4	Improvement	NA	No	No	No
5	Improvement	NA	No	No	No
6	Improvement	NA	No	No	No
7	Disease aggravation	NA	No	No	No
8	Death	Infection	No	No	No
9	Improvement	NA	No	No	No
10	Improvement	NA	No	No	No
11	Death	Hematologic malignancy	Yes	Yes	No
12	Improvement	NA	No	No	No
13	Disease aggravation	NA	Yes	Yes	No
14	Improvement	NA	No	No	No
15	Improvement	NA	No	No	No
16	Death	Hematologic malignancy and HPS	Yes	No	No
17	Disease aggravation	NA	No	No	No
18	Improvement	NA	No	No	No
19	Improvement	NA	No	No	No
20	Improvement	NA	No	No	No
21	Improvement	NA	No	No	No
22	Improvement	NA	No	No	No
23	Disease aggravation	NA	No	No	No
24	Improvement	NA	No	No	No
25	Improvement	NA	No	No	No

Abbreviations: ISZ, Isavuconazole; ADR, Adverse drug reactions; NA, Not applicable; HPS, Hemophagocytic syndrome.