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. Author manuscript; available in PMC: 2025 Apr 28.
Published in final edited form as: Psychopharmacology (Berl). 2024 Nov 8;242(3):593–615. doi: 10.1007/s00213-024-06711-9

Fig. 5. Unconditioned manipulation of outcome value via cocaine pretreatment alters anticipation and consumption of cocaine under the FI-FR response chain.

Fig. 5

A) Representative response records for behavior during the first trial after cocaine infusion (bottom). Corresponding estimates for momentary brain cocaine levels (top; dotted lines). B) Mean (± SEM) FI responses, cocaine intake and latency to first self-administered infusion following a non-contingent cocaine priming infusion (top). No behavioral compensation for drug pre-loading is evident in subsequent trials. Mean (± SEM) FI responses and cocaine intake averaged across the last 3 trials of test session, which were not preceding by a cocaine prime (bottom). *p<.05, ,**p < .01,***p < 0.001