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. Author manuscript; available in PMC: 2025 Apr 29.
Published in final edited form as: Leukemia. 2007 Nov 8;22(6):1268–1272. doi: 10.1038/sj.leu.2405027

Figure 3.

Figure 3

Metaphase fluorescence in situ hybridization (FISH) demonstrating both IGH-BCL6 fusion and IGH-IRF4/MUM1 fusion in the same cells in a splenic marginal zone lymphoma specimen with an abnormal karyotype (46,XX, + X,t(3;14)(q27;q32), −6,t(6;14)(p25;q32), der(17)t(6;17)(p21;p13)). (a) A two-color IGH-BCL6 dual fusion FISH probe shows two yellow fusion signals (yellow arrows) indicating IGH-BCL6 fusion as well as an extra green IGH signal (green arrows) consistent with the presence of IGH-IRF4/MUM1 fusion on the other allele. (b) A two-color IGH-IRF4/MUM1 D-FISH probe shows two yellow fusion signals (yellow arrows) indicating IGH-IRF4/MUM1 fusion as well as an extra green IGH signal (green arrows) consistent with the presence of IGH-BCL6 fusion on the other allele.