Table 4.
Associations between maternal plasma PFAS levels after delivery and inversely normalized measles VARscore during early childhood in 348 post-vaccination children, stratified by infant feeding modality.
PFAS | Exclusively Formula-fed (N = 72) | Any breastfeda (N = 272) | P for interaction PFAS × Feeding | ||
---|---|---|---|---|---|
(log2-transformed) | Beta ± SE | P | Beta ± SE | P | |
Me-PFOSA-AcOH | −0.08 ± 0.09 | 0.392 | −0.08 ± 0.04 | 0.055 | 0.885 |
PFDeA | −0.06 ± 0.15 | 0.702 | 0.04 ± 0.05 | 0.433 | 0.390 |
PFHpS | −0.19 ± 0.11 | 0.097 | −0.07 ± 0.05 | 0.198 | 0.229 |
PFHxS | −0.18 ± 0.09 | 0.053 | −0.07 ± 0.04 | 0.128 | 0.107 |
PFNA | −0.10 ± 0.19 | 0.590 | 0.08 ± 0.06 | 0.211 | 0.174 |
PFOA | −0.19 ± 0.12 | 0.097 | −0.06 ± 0.06 | 0.418 | 0.184 |
PFOS | −0.33 ± 0.14 | 0.017 | −0.04 ± 0.06 | 0.450 | 0.041 |
PFUnA | 0.07 ± 0.11 | 0.562 | −0.03 ± 0.04 | 0.483 | 0.411 |
PFAS burden score | −0.35 ± 0.21 | 0.104 | −0.01 ± 0.09 | 0.936 | 0.053 |
Adjusted for maternal race and ethnicity, maternal age at delivery, maternal smoking during pregnancy, delivery type, sex, preterm birth and years since last vaccination
This group included “both formula-fed and breast-fed” and “exclusively breast-fed” children. Four children with missing data on feeding modality were excluded from this analysis.