Table 2.

Multivariable analysis of the association with lung function (FEV₁PP) in people with cystic fibrosis

Variable	Estimate	Confidence Interval	P Value
Discontinuous care	−0.81	−1.00, −0.61	<0.001
Race/ethnicity*
Hispanic	−5.93	−6.91, −4.95	<0.001
White	1.20	−1.12, 3.53	0.3
African American	−0.88	−3.16, 1.40	0.4
Other race	4.83	2.54, 7.12	<0.001
Genotype
F508del heterozygotes		Reference
F508del homozygotes	−2.82	−3.35, −2.28	<0.001
Other or unknown mutation	0.26	−0.50, 1.01	0.5
Male sex	0.72	0.23, 1.20	0.004
Insurance coverage	−1.02	−1.08, −0.95	<0.001
Private insurance/military/parent’s insurance		Reference
Medicare/Medicaid/state program/IHS	−0.84	−0.92, −0.76	<0.001
Other insurance	−0.84	−1.15, −0.53	<0.001
No insurance	−0.09	−0.37, 0.19	0.5
Unknown insurance status	−1.20	−1.40, −1.01	<0.001
Underweight BMI	−8.20	−8.29, −8.11	<0.001
CF-related diabetes	−3.12	−3.21, −3.03	<0.001
Chronic infection
Pseudomonas aeruginosa	0.14	0.04, 0.24	0.004
MRSA	−1.19	−1.28, −1.09	<0.001
Burkholderia spp.	−1.98	−2.19, −1.76	<0.001

Definition of abbreviations: BMI = body mass index; CF = cystic fibrosis; CFFPR = Cystic Fibrosis Foundation Patient Registry; FEV₁PP = percentage predicted forced expiratory volume in 1 second; IHS = Indian Health Service; MRSA = methicillin-resistant Staphylococcus aureus.

^*Individuals were able to endorse multiple race/ethnicity categories. Estimates are from Model 1 (multivariable semiparametric regression analysis) which includes 24,328 individuals with cystic fibrosis in the CFFPR between 2004 and 2016.