Figure 5.
Comparison of immunofluorescence staining results between WT and PdgfbcTG mice. (A-D) show representative microscope images from the cortex, hippocampus, striatum, and olfactory area, respectively. The scale bar corresponds to 200 µm. Zoomed-in images (right two panels) highlight the co-localization of CD13 and CD31. White arrows indicate normal pericytes in different regions, while yellow arrows point to detached pericytes in the cortex, hippocampus, and olfactory area of PdgfbcTG mice. Vessel density was quantified as the ratio of the CD31+ area to the total regional area. Pericyte coverage was quantified as the ratio of the CD13+ area to the CD31+ area. (E), (G), (I), and (K) present comparisons of vessel density in the cortex, hippocampus, striatum, and olfactory area, respectively. (F), (H), (J), and (L) show comparisons of pericyte coverage in the cortex, hippocampus, striatum, and olfactory area, respectively.