Table 4.

Measures of efficacy

Variable	DL-1 % (n)	DL-2 % (n)	DL-3 % (n)	Overall % (n)
Median Treatment Duration (weeks)	11.7	34.3	8	11.4
Best Response
Stable Disease	33.3 (1)	33.3 (1)	50.0 (2)	40.0 (4)
Progressive Disease	66.7 (2)	66.7 (2)	66.7 (2)	60.0 (6)
Reason for Treatment Discontinuation
Progressive disease	100.0 (3)	66.7 (2)	100.0 (4)	90.0 (9)
Physician Decision	0	33.3 (1)	0	10.0 (1)
Reason off Study
Study Completion	0	33.3 (1)	0	10.0 (1)
Disease progression	66.7 (2)	66.7 (2)	25.0 (1)	50.0 (5)
On Follow up	33.3 (1)	0	75.0 (3)	40.0 (4)
Survival Summary
Median PFS (95% CI; Months)	2.7 (2.6 – 32.2)	9.1 (7.9 – 16.9)	1.8 (1.8 – 2.3)	2.6 (1.8 – 9.1)
Median OS (95% CI; Months)	18.8 (10.3 – NR)	28.1 (16.9 – 28.7)	NR (6.4 – NR)	18.8 (6.4 – 28.7)