Table 3.

Summary of data collection and data analysis approaches.

	Type and setup of device				Follow-up			Other outcome measures		Data analysis
Study	Body location	Device (type and name)	Sampling frequency (Hz)	Duration of follow-up		Duration and frequency of measurements	Outcome measures		Epochs used in analysis (s)
van Eijk et al [24]	Right hip (anterior axillary line)	Triaxial accelerometer ActiGraph GT9XLink	30	18 mo		7 consecutive d every 2-3 mo	ALSFRS-Ra, Hospital Anxiety and Depression Scale, weight, wear time log		10
Garcia-Gancedo et al [20]	Chest	Triaxial accelerometer Mega faros 180	50	48 wk		3 consecutive d every mo	ALSFRS-R, forced vital capacity, heart rate variability, speech		60
Kelly et al [22]	Chest	Triaxial accelerometer; Mega Faros 180	50	48 wk		3 consecutive d every mo	ALSFRS-R, forced vital capacity, heart rate variability, speech		60 (based on information from Garcia-Gancedo et al. [20])
Rutkove et al [21]	Not stated Device designed for wrist	Mi Band R	Not reported	9 mo		Daily for 90 d, then biweekly for 180 d	ALSFRS-R, speech, electrical impedance myography tool, respiratory data, muscle strength, patient-reported experience measures		Not relevant
Rutkove et al [23]	Not stated Device designed for wrist	Mi Band R	Not reported	9 mo		Daily for 90 d, then biweekly for 180 d	ALSFRS-R, speech, electrical impedance myography tool, respiratory data, muscle strength, patient-reported experience measures		Not relevant
Karas et al [25]	Not relevant	Personal phone (triaxial accelerometer and GPS)	10 (accelerometer)	Up to 1 y		Continuous cyclical accelerometer 10 s on or off GPS 1 min on or 10 min off	ALSFRS-RSEb		60
Holdom et al [26]	Wrist (nondominant), right hip	Triaxial accelerometer ActiGraph GT9XLink	30	18 mo		Wrist—8 consecutive d every 3-4 months and hip—7 consecutive d every 2-3 mo	ALSFRS-R		10
Johnson et al [27]	Wrist or ankle	Wrist: triaxial accelerometer ActiGraph Insight Watch, Ankle: biaxial accelerometer Modus StepWatch 4	Wrist: 32 and ankle: 128	6 mo		As much as possible for the duration of the study	ALSFRS-R, ALSFRS-RSE, Rasch-Built Overall ALSc Disability Scale		60
Gupta et al. [28]	All 4 limbs (wrists and ankles)	Triaxial accelerometer ActiGraph GT3X	30	Minimum of 0.75 y stated		7 d every mo	ALSFRS-R		1
van Unnik et al [29]	Right hip (anteroaxillary line)	Triaxial accelerometer ActiGraph GT9XLink	30	18-24 mo		3-7 d every 2-3 mo	Survival status, ALSFRS-R (self-administered or physician administered)		10
Beswick et al [30]	Right wrist and Right ankle	Triaxial accelerometer ActiGraph GT9X	Not disclosed	12 wk		24 h every 2 wk	ALSFRS-R, 6-minute walking test, questionnaires to provide feedback on their experience of wearing devices, standardized series of movements		Not disclosed
Straczkiewicz et al [31]	Wrist of choice	Triaxial accelerometer ActiGraph, Insight Watch	32	6 mo		Continuously, except for recharging (required every few weeks)	ALSFRS-RSE		60 (for total activity counts)

^aALSFRS-R: Amyotrophic Lateral Sclerosis Functional Rating Scale-Revised.

^bALSFRS-RSE: Amyotrophic Lateral Sclerosis Functional Rating Scale self-administered.

^cALS: amyotrophic lateral sclerosis.