Table 2. Etiologies of chronic cough in 298 patients, as determined using the pathophysiological diagnostic procedure and demographic characteristics, clinical features, and pulmonary function tests.
|
- |
AC |
CVA |
CPA |
SBS |
Unknown |
AC+CVA |
AC+CPA |
|
Number of pts (No. of Fem) |
3 (3) |
82 (56) |
4 (3) |
4 (1) |
9 (5) |
52 (21) |
2 (1) |
|
Age (years) |
66±14 |
52±17 |
64±123 |
67±17 |
67±11 |
50±18 |
53±13 |
|
FVC (%pred.) (%) |
124±4 |
107±15 |
105±18 |
106±11 |
110±14 |
102±17 |
90±16 |
|
FEV1 (%pred.) (%) |
120±8 |
102±13 |
102±10 |
97±29 |
109±17 |
96±16 |
79±17 |
|
FEV1/FVC ratio (%) |
76±2 |
80±8 |
79±7 |
72±17 |
80±6 |
81±9 |
73±6 |
|
Meth-C test |
15±3 |
117±82 |
11±11 |
16±9 |
9±6 |
124±113 |
7 |
|
C5 (µM) |
1±1 |
7±1 |
6±2 |
31±1 |
17±2 |
2±1 |
2±2 |
|
Sputum nut (%) |
71±16 |
54±31 |
32±10 |
51±30 |
71±15 |
70±24 |
32±7 |
|
Sputum eos (%) |
0±0 |
11±24 |
1±1 |
25±19 |
3±2 |
7±14 |
26±25 |
|
Blood eos (%) |
3±2 |
3±5 |
2±1 |
4±3 |
3±3 |
3±2 |
5±1 |
|
Total IgE level (IU/mL) |
183±31 |
251±562 |
26±7 |
2673±3258 |
283±577 |
281±542 |
173±168 |
|
Positive rate of specific IgE (%) |
100 |
51 |
0 |
50 |
22 |
51 |
50 |
|
- |
AC+SBS |
CPA+SBS |
CVA+SBS |
AC+CVA+SBS |
CVA+MISB+SBS |
CPA+MISB+SBS |
AC+CVA+MISB+SBS |
|
Number of pts (No. of Fem) |
9 (3) |
9 (6) |
76 (54) |
35 (17) |
3 (3) |
2 (2) |
2 (1) |
|
Age (years) |
69±4 |
67±13 |
59±15 |
64±14 |
68±10 |
61±24 |
68±4 |
|
FVC (%pred.) (%) |
91±21 |
109±12 |
101±16 |
105±18 |
78±7 |
97±9 |
100±6 |
|
FEV1 (%pred.) (%) |
85±12 |
100±9 |
95±17 |
99±21 |
65±15 |
767±15 |
89±4 |
|
FEV1/FVC ratio (%) |
77±9 |
74±5 |
78±8 |
77±9 |
66±15 |
63±11 |
72±1 |
|
Meth-C test |
13±7 |
17±11 |
123±96 |
119±87 |
86±62 |
16±5 |
153±102 |
|
C5 (µM) |
2±1 |
10±1 |
8±0 |
1±1 |
12±1 |
16±2 |
2±2 |
|
Sputum nut (%) |
79±17 |
71±16 |
62±25 |
67±21 |
74±11 |
60±35 |
95±1 |
|
Sputum eos (%) |
5±3 |
11±16 |
13±21 |
12±20 |
11±7 |
26±25 |
2.0±0 |
|
Blood eos (%) |
2±1 |
3±2 |
4±4 |
3±3 |
2±1 |
5±5 |
2±1 |
|
Total IgE level (IU/mL) |
291±575 |
107±100 |
268±687 |
147±254 |
104±47 |
64±33 |
399±391 |
|
Positive rate of specific IgE (%) |
22 |
11 |
46 |
46 |
100 |
50 |
50 |
|
- |
Others |
- |
- |
- |
- |
- |
- |
|
Number of pts (No. of Fem) |
6 (3) |
- |
- |
- |
- |
- |
- |
|
Age (years) |
64±15 |
- |
- |
- |
- |
- |
- |
|
FVC (%pred.) (%) |
88±15 |
- |
- |
- |
- |
- |
- |
|
FEV1 (%pred.) (%) |
82±15 |
- |
- |
- |
- |
- |
- |
|
FEV1/FVC ratio (%) |
75±7 |
- |
- |
- |
- |
- |
- |
|
Meth-C test |
41±67 |
- |
- |
- |
- |
- |
- |
|
C5 (µM) |
14±2 |
- |
- |
- |
- |
- |
- |
|
Sputum nut (%) |
74±12 |
- |
- |
- |
- |
- |
- |
|
Sputum eos (%) |
3±1 |
- |
- |
- |
- |
- |
- |
|
Blood eos (%) |
4±3 |
- |
- |
- |
- |
- |
- |
|
Total IgE level (IU/mL) |
59±31 |
- |
- |
- |
- |
- |
- |
|
Positive rate of specific IgE (%) |
67 |
- |
- |
- |
- |
- |
- |
Others including the following patients, DPB 1 patient, MISB 1 patient, CPA+MISB 1 patient, SBS+Bronchorrhea 1 patient, AC+CVA+DPB 1 patient, AC+CVA+MISB 1 patient.
AC: atopic cough, CPA: cough predominant asthma, CVA: cough variant asthma, DPB: diffuse panbronchiolitis, eos: eosinophils, Fem: female, FVC: forced vital capacity, FEV1: forced expiratory volume in 1 s, FeNO: fractional exhaled nitric oxide, MISB: mucoid impaction of small bronchi, nut: neutrophils, pts: patients, pred.: predicted, SBS: sinobronchial syndrome, IgE: immunoglobulin E