Table 3. Multivariate linear regression analyses of low PWR (< 26.3) as a risk factor for worse liver function in patients with WD.

	Beta	Standard error	P value
Liver injury parameters
ALT (U/L)	–	–	–
AST (U/L)	–	–	–
Total bilirubin (μmol/L)	8.83	2.10	<0.001
Synthetic function parameters
Albumin (g/L)	−1.97	0.58	0.001
Total cholesterol (mmol/L)	−0.48	0.12	<0.001
HDL-C (mmol/L)	–	–	–
LDL-C (mmol/L)	−0.33	0.11	0.003
Triglyceride (mmol/L)	−0.24	0.11	0.024
Coagulation parameters
INR	0.26	0.04	<0.001
PT (s)	2.25	0.34	<0.001
Liver fibrosis parameters
PIIINP (μg/mL)	12.63	6.19	0.042
Type IV collagen (ng/mL)	11.70	2.46	<0.001
Hyaluronic acid (ng/mL)	97.27	20.22	<0.001
Laminin (ng/mL)	–	–	–
Portal vein diameter (mm)	0.87	0.27	0.002

Note:

Analyses were adjusted for age, sex, BMI, smoking, alcoholism, hypertension, diabetes, and anti-copper treatment. ALT, alanine transaminase; AST, aspartate transaminase; BMI, body mass index; HDL-C, high-density lipoprotein cholesterol; INR, international normalized ratio; LDL-C, low-density lipoprotein cholesterol; PIIINP, procollagen type III terminal propeptide; PT, prothrombin time; PWR, platelet-to-white blood cell ratio; WD, Wilson disease