Table 2.
Comparison of immunotherapy-related markers between DDR-MT and DDR-WT
| All | MSS/pMMR | MSI-H/dMMR | |||||||
|---|---|---|---|---|---|---|---|---|---|
| DDR-MT (N = 1290) |
DDR-WT (N = 8031) |
P-value | DDR-MT (N = 829) |
DDR-WT (N = 7873) |
P-value | DDR-MT (N = 456) |
DDR-WT (N = 141) |
P-value | |
| TMB (Mean) | 20.9/Mb | 7.7/Mb | < .001 | 13.7/Mb | 7.6/Mb | .02 | 54.5/Mb | 27.8/Mb | < .001 |
| TMB-H (≥17/Mb) |
38.1% | 2.1% | < .001 | 5.6% | 0.6% | < .001 | 97.1% | 84.1% | < .001 |
| TMB-H (≥10/Mb) |
52.3% | 20.7% | < .001 | 26.3% | 19.4% | < .001 | 99.3% | 94.2% | < .001 |
| PD-L1 ≥5% | 10.1% | 2.7% | < .001 | 4.8% | 2.4% | < .001 | 19.8% | 20.4% | .87 |
Abbreviations: DDR, DNA damage response; dMMR, mismatch repair deficient; MSI-H, microsatellite instability high; MSS, microsatellite stable; MT, mutant; pMMR, mismatch repair proficient; TMB, tumor mutation burden; TMB-H, tumor mutation burden high; WT, wild type.