Table 2.
LLDAS attainment and outcomes of HDAS patients at annual follow-up visits
| Year 1 | Year 2 | Year 3 | Year 4 | Year 5 | |
|---|---|---|---|---|---|
| Total=824 | Total=617 | Total=489 | Total = 354 | Total=249 | |
| n (%) | n (%) | n (%) | n (%) | n (%) | |
| LLDAS | |||||
| LLDAS-ever (at least once) | 293 (37.1%) | 330 (56.8%) | 308 (66.1%) | 251 (74.3%) | 194 (77.9%) |
| LLDAS-50 | 111 (14.1%) | 128 (22.0%) | 122 (26.2%) | 99 (29.3%) | 73 (29.3%) |
| ≥3 months sustained LLDAS, ever | 89 (11.3%) | 169 (29.1%) | 190 (40.8%) | 171 (50.6%) | 141 (56.6%) |
| ≥6 months sustained LLDAS, ever | 46 (5.8%) | 125 (21.5%) | 152 (32.6%) | 141 (41.7%) | 118 (47.4%) |
| ≥12 months sustained LLDAS, ever | 0 | 40 (6.9%) | 70 (15.0%) | 74 (21.9%) | 65 (26.1%) |
| ≥24 months sustained LLDAS, ever | 0 | 0 | 22 (4.7%) | 32 (9.5%) | 28 (11.2%) |
| REM | |||||
| REM, ever | 175 (22.2%) | 248 (42.7%) | 245 (52.6%) | 196 (58.0%) | 160 (64.3%) |
| REM-50 | 70 (8.9%) | 83 (14.3%) | 81 (17.4%) | 77 (22.8%) | 57 (22.9%) |
| ≥3 months sustained REM, ever | 64 (8.1%) | 131 (22.5%) | 153 (32.8%) | 144 (42.6%) | 123 (49.4%) |
| ≥6 months sustained REM, ever | 30 (3.8%) | 91 (15.7%) | 118 (25.3%) | 113 (33.4%) | 98 (39.4%) |
| ≥12 months sustained REM, ever | 0 | 26 (4.5%) | 51 (10.9%) | 62 (18.3%) | 57 (22.9%) |
| ≥24 months sustained REM, ever | 0 | 0 | 10 (2.1%) | 24 (7.1%) | 23 (9.2%) |
| Outcomes | |||||
| Patients with organ damage accrual | 88 (11.2%) | 106 (18.2%) | 114 (24.5%) | 98 (29.0%) | 85 (34.1%) |
| M/M/S flare ever | 614 (77.8%) | 495 (85.2%) | 411 (88.2%) | 310 (91.7%) | 239 (96.0%) |