Table 1. Effect of carvedilol on inhibiting bedaquiline metabolism in RLM/HLM/CYP3A4 and corresponding IC₅₀ values.

	Inhibition type	Ki (µM)	αKi (µM)	α	IC50 values (µM)
RLM	Mixed	4.56	61.32	13.45	15.35 ± 0.43
HLM	Un–Competitive	–	8.44	–	7.55 ± 0.74
CYP3A4	Mixed	0.32	0.13	0.41	0.79 ± 0.05