Table 3. Main pharmacokinetic parameters of M2 in two groups of rats (n = 4).
| Parameters | Bedaquiline (10 mg/kg) | Bedaquiline (10 mg/kg) + Carvedilol (5 mg/kg) |
|---|---|---|
| AUC(0−t)(ng/mL*h) | 1,550.69 ± 831.88 | 1,238.59 ± 641.31 |
| AUC(0−∞) (ng/mL*h) | 2,133.95 ± 1,376.90 | 1,886.52 ± 938.03 |
| t1/2z (h) | 19.68 ± 1.22 | 18.44 ± 4.57 |
| Tmax (h) | 33.69 ± 9.11 | 39.63 ± 8.77 |
| Vz/F (L/kg) | 21.22 ± 6.53 | 25.32 ± 4.80 |
| CLz/F (L/h/kg) | 9.00 ± 2.58 | 10.00 ± 1.63 |
| Cmax (ng/mL ) | 176.37 ± 72.07 | 258.09 ± 178.02 |
Notes.
- AUC
- area under the plasma concentration–time curve
- t1/2z
- elimination half time
- Tmax
- peak time
- Vz/F
- apparent volume of distribution
- CLz/F
- plasma clearance
- Cmax
- maximum plasma concentration