FIGURE 7.

Stability of compounds in human plasma. Data are presented as the means ± SD of four independent experiments, each performed in duplicate. A 5 µM dose of each compound was incubated with human plasma for up to 24 h. Following 2‐way repeated measures ANOVA analyses, there were significant effects of time (F (2, 6) = 8.135; p = 0.02), compounds (F (1, 3) = 57.32; p = 0.005) and their interaction (F (2, 6) = 58.21; p = 0.0001). At different time points, values without common superscripts within compounds are considered statistically significant, and values with an asterisk * are different from OB‐CAPE (5) at the same time point as determined using Tukey's multiple comparisons test (p < 0.05).