. 2025 May 5;86(3):e70099. doi: 10.1002/ddr.70099

TABLE 5.

Physicochemical properties and partition coefficients of studied compounds.

	Physicochemical properties ^a				Lipophilicity ^a
	MW	n‐ROTB	n‐HBA	n‐HBD	CLogP_o/w
Rule	$<$ 500	$\leq$ 10	$<$ 10	$<$ 5	$<$ 5
OB‐CAPE (5)	308.33	5	5	2	3.09
CAPE (1)	284.31	6	4	2	3.08
Zileuton (3)	236.29	3	2	2	1.81

Abbreviations: CLog P_o/w, logarithm of compound partition coefficient between n‐octanol and water; MW, molecular weight (g/mol); n‐HBA, number of hydrogen bonds acceptors; n‐HBD, number of hydrogen bond donors; n‐ROTB, number of rotatable bonds.

^{^a}

SwissADME (Daina et al. 2017).