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. 2025 May 6;14(5):e70083. doi: 10.1002/jev2.70083

FIGURE 3.

FIGURE 3

Association of m6A levels in tumour Te‐EVs with inflammatory status of clinical tumour tissues. Correlation analysis of m6A levels in tumour small Te‐EVs and the amount of TNF‐α (A) or IL‐6 (B) released from tumour small Te‐EV‐treated monocyte‐derived macrophages (MDMs). Spearman's correlation coefficient r was calculated. Correlation analysis of m6A levels in tumour large Te‐EVs and the amount of TNF‐α (C) or IL‐6 (D) released from tumour large Te‐EV‐treated MDMs. Spearman's correlation coefficient r was calculated. (E) Immunohistochemical analysis of TNF‐α, IL‐6 and CD68 expression in colorectal cancer clinical tissue with or without recurrence. Representative images are shown (21 tumour tissues obtained from recurrence‐free patients and eight tumour tissues from relapsed patients). The scale bar shows 100 µm. H‐score of TNF‐α (F) IL‐6 (G) and CD68 (H) expression. Mann–Whitney test; **p < 0.01, ***p < 0.001, ns, not significant. Correlation analysis of m6A levels in tumour small Te‐EVs and the H‐scores of TNF‐α (I) or IL‐6 (J) in corresponding colorectal cancer clinical tissues. Spearman's correlation coefficient (r) was calculated. Correlation analysis of m6A levels in tumour large Te‐EVs and the H‐scores of TNF‐α (K) or IL‐6 (L) in corresponding colorectal cancer clinical tissues. Spearman's correlation coefficient (r) was calculated.