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. 2025 Apr 23;58:101554. doi: 10.1016/j.lanwpc.2025.101554

Table 2.

Cause-specific excess mortality in Hong Kong (January 2020–June 2024).

Observed deaths Observed mortality per 100,000 Excess mortality per 100,000 (95% CI) Age-adjusted excess mortality per 100,000 (95% CI) % of age adjusted excess deaths to baseline deaths (95% CI)
Respiratory diseases 70,052 208.96 37.86 (36.26, 39.47) 41.10 (39.58, 42.62) 23.55 (22.68, 24.42)
 Pandemic (before Omicron) 25,446 170.85 3.47 (1.10, 5.85) 3.93 (1.67, 6.19) 2.29 (0.97, 3.60)
 Pandemic (Omicron) 20,783 282.91 106.34 (102.98, 109.71) 108.71 (105.52, 111.90) 62.41 (60.58, 64.24)
 Post pandemic 23,823 222.81 37.33 (34.47, 40.20) 44.87 (42.19, 47.54) 25.21 (23.71, 26.71)
 Influenza 377 1.12 −2.70 (−2.95, −2.44) −2.74 (−2.99, −2.49) −71.08 (−77.63, −64.54)
 Pandemic (before Omicron) 30 0.20 −2.77 (−3.10, −2.44) −2.79 (−3.12, −2.46) −93.62 (−104.76, −82.49)
 Pandemic (Omicron) 0 0.00 −3.65 (−4.16, −3.13) −3.75 (−4.27, −3.23) −102.80 (−117.08, −88.52)
 Post pandemic 347 3.08 −1.94 (−2.46, −1.43) −1.88 (−2.37, −1.40) −67.96 (−85.40, −50.51)
 Pneumonia 52,484 156.55 14.83 (13.41, 16.26) 17.81 (16.45, 19.16) 12.39 (11.44, 13.33)
 Pandemic (before Omicron) 21,723 145.85 8.56 (6.46, 10.66) 9.03 (7.01, 11.05) 6.40 (4.97, 7.83)
 Pandemic (Omicron) 12,421 169.08 23.25 (20.26, 26.24) 25.54 (22.68, 28.39) 17.79 (15.80, 19.78)
 Post pandemic 18,340 162.52 17.54 (14.99, 20.10) 23.06 (20.79, 25.33) 16.54 (14.91, 18.16)
 Chronic obstructive pulmonary disease 1850 5.52 −1.29 (−1.57, −1.00) −1.25 (−1.53, −0.96) −17.97 (−22.10, −13.84)
 Pandemic (before Omicron) 756 5.08 −1.95 (−2.39, −1.52) −1.96 (−2.40, −1.53) −27.30 (−33.38, −21.22)
 Pandemic (Omicron) 408 5.55 −1.23 (−1.83, −0.64) −1.24 (−1.84, −0.64) −18.25 (−27.03, −9.47)
 Post pandemic 686 6.08 −0.42 (−0.91, 0.08) −0.27 (−0.73, 0.20) −4.23 (−11.56, 3.09)
 Lung diseases due to external agents 1997 5.96 −1.16 (−1.46, −0.87) −1.01 (−1.31, −0.72) −14.17 (−18.23, −10.11)
 Pandemic (before Omicron) 927 6.22 −1.07 (−1.51, −0.62) −1.04 (−1.48, −0.59) −13.94 (−19.91, −7.97)
 Pandemic (Omicron) 478 6.51 −0.77 (−1.38, −0.15) −0.64 (−1.25, −0.03) −9.00 (−17.55, −0.44)
 Post pandemic 592 5.25 −1.56 (−2.07, −1.06) −1.17 (−1.64, −0.71) −18.27 (−25.55, −10.99)
Non-respiratory diseases 115,186 343.59 3.48 (1.37, 5.59) 4.33 (2.23, 6.42) 1.23 (0.63, 1.82)
 Pandemic (before Omicron) 50,646 340.04 2.70 (−0.45, 5.85) 1.87 (−1.26, 5.01) 0.53 (−0.36, 1.43)
 Pandemic (Omicron) 26,584 361.88 11.32 (6.88, 15.76) 10.05 (5.63, 14.48) 2.83 (1.59, 4.08)
 Post pandemic 37,956 357.86 −0.86 (−4.57, 2.86) 3.70 (0.04, 7.36) 1.05 (0.01, 2.08)
 Heart disease 16,560 49.40 0.04 (−0.77, 0.85) 0.56 (−0.22, 1.34) 1.12 (−0.44, 2.68)
 Pandemic (before Omicron) 7341 49.29 −0.86 (−2.09, 0.37) −0.85 (−2.04, 0.33) −1.66 (−3.97, 0.65)
 Pandemic (Omicron) 3843 52.31 2.00 (0.30, 3.70) 2.27 (0.63, 3.91) 4.56 (1.27, 7.85)
 Post pandemic 5376 47.64 −0.09 (−1.50, 1.32) 1.23 (−0.04, 2.51) 2.67 (−0.09, 5.43)
 Cerebrovascular disease 8761 26.13 1.86 (1.31, 2.42) 1.97 (1.42, 2.51) 7.87 (5.69, 10.05)
 Pandemic (before Omicron) 3930 26.39 1.82 (0.99, 2.66) 1.76 (0.93, 2.58) 6.91 (3.67, 10.15)
 Pandemic (Omicron) 2007 27.32 2.39 (1.23, 3.56) 2.35 (1.20, 3.50) 9.41 (4.82, 14.00)
 Post pandemic 2824 25.03 1.55 (0.58, 2.51) 1.88 (0.99, 2.77) 8.13 (4.29, 11.98)
 Neoplasms 40,172 119.83 −8.21 (−9.46, −6.96) −10.02 (−11.29, −8.76) −7.50 (−8.45, −6.55)
 Pandemic (before Omicron) 18,010 120.92 −8.20 (−10.07, −6.32) −9.25 (−11.15, −7.35) −6.91 (−8.33, −5.49)
 Pandemic (Omicron) 8807 119.89 −11.84 (−14.46, −9.21) −14.81 (−17.49, −12.14) −11.00 (−12.98, −9.01)
 Post pandemic 13,355 118.35 −5.73 (−7.90, −3.57) −7.37 (−9.45, −5.28) −5.86 (−7.52, −4.20)
 Nephritis and nephrosis 5901 17.60 0.41 (−0.05, 0.87) 0.51 (0.05, 0.96) 2.87 (0.28, 5.46)
 Pandemic (before Omicron) 2591 17.40 0.70 (0.03, 1.38) 0.65 (−0.03, 1.32) 3.74 (−0.18, 7.67)
 Pandemic (Omicron) 1417 19.29 1.64 (0.68, 2.60) 1.63 (0.67, 2.59) 9.22 (3.77, 14.66)
 Post pandemic 1893 16.78 −0.83 (−1.65, −0.01) −0.43 (−1.20, 0.34) −2.50 (−6.95, 1.95)
 Dementia 1058 3.16 −1.00 (−1.23, −0.78) −0.95 (−1.18, −0.73) −22.66 (−27.96, −17.36)
 Pandemic (before Omicron) 456 3.06 −0.56 (−0.88, −0.24) −0.58 (−0.90, −0.27) −15.61 (−24.05, −7.18)
 Pandemic (Omicron) 269 3.66 −0.66 (−1.14, −0.18) −0.63 (−1.10, −0.15) −14.59 (−25.63, −3.55)
 Post pandemic 333 2.95 −1.84 (−2.27, −1.42) −1.59 (−1.98, −1.20) −35.04 (−43.70, −26.39)
 Injury 3356 10.01 0.28 (−0.06, 0.63) 0.23 (−0.11, 0.58) 2.29 (−1.13, 5.72)
 Pandemic (before Omicron) 1491 10.01 0.62 (0.11, 1.13) 0.53 (0.02, 1.04) 5.44 (0.21, 10.66)
 Pandemic (Omicron) 743 10.11 0.04 (−0.68, 0.77) −0.06 (−0.79, 0.67) −0.61 (−7.79, 6.58)
 Post pandemic 1122 9.94 0.00 (−0.62, 0.61) 0.03 (−0.56, 0.61) 0.26 (−5.61, 6.13)

Pandemic (before Omicron): 2020-01-23–2021-12-31; Pandemic (Omicron): 2022-01-01–2022-12-31; Post pandemic: 2023-01-01–2024-06-01. Mid-year population sizes were used to be the denominators of mortality rates.