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The interaction between GPR158 and related proteins. GPR158 interacts with HSPGs and LAR to promote cell differentiation, inhibits β-secretase to reduce Aβ and amyloid plaque formation, and enhances BDNF expression via RbAp48. Additionally, GPR158 binds RGS7, facilitating its membrane localization and forming a negative feedback loop by promoting GTPase activity. GPR158 also interacts with RGS7 to inhibit the GTPase. APP, amyloid precursor protein; C99, β-CTF fragment of APP.
