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. 2025 May 6;16:4211. doi: 10.1038/s41467-025-58937-6

Table 2.

Measurable indicators and biochemical parameters at the end of intervention

HP-L HP-D HM-L HM-D Ptiming Value Ptype Value Pinteraction Value
Body weight (kg) 65.56 ± 10.26 64.90 ± 8.83 66.48 ± 10.60 65.68 ± 5.73 0.811 0.815 0.977
BMI (kg/m2) 25.07 ± 2.45 25.96 ± 2.37 25.59 ± 2.78 26.11 ± 2.96 0.591 0.882 0.789
Fat mass% 31.29 ± 4.42 32.24 ± 5.32 30.72 ± 4.61 33.41 ± 6.89 0.178 0.555 0.536
Fasting glucose (mg/dL) 94.48 ± 9.89 96.13 ± 10.98 92.03 ± 8.07 94.57 ± 13.14 0.517 0.691 0.873
Postprandial glucose (mg/dL) 127.42 ± 15.85 133.44 ± 17.48 128.35 ± 18.44 131.80 ± 17.55 0.589 0.796 0.774
AUCglu (mg/dL*h) 276.89 ± 26.99 315.65 ± 50.01 299.16 ± 38.24 291.59 ± 46.44 0.618 0.117 0.034
HbA1c (%) 6.05 ± 0.23 6.21 ± 0.22 6.10 ± 0.20 6.23 ± 0.45 0.237 0.820 0.869
HbA1c (mmol/mol) 42.61 ± 2.54 44.31 ± 2.44 43.16 ± 2.23 44.58 ± 4.96 0.235 0.818 0.871
Fasting insulin (mIU/mL) 6.39 ± 2.94 6.87 ± 2.75 6.92 ± 3.47 7.87 ± 4.23 0.447 0.422 0.787
Postprandial insulin (mIU/mL) 18.00 ± 13.59 32.54 ± 17.06 11.01 ± 5.23 34.80 ± 25.97 <0.001* 0.719 0.301
AUCins (mIU/mL*h) 64.19 ± 46.50 71.46 ± 38.14 60.02 ± 34. 26 74.18 ± 50.25 0.369 0.862 0.756
Gutt index 107.12 ± 29.07 79.86 ± 14.56 112.15 ± 15.06 86.92 ± 27.68 0.003* 0.397 0.863
Stumvoll index 0.105 ± 0.013 0.094 ± 0.013 0.108 ± 0.011 0.092 ± 0.019 0.003* 0.690 0.457
Triglycerides (mmol/L) 1.42 ± 0.60 1.56 ± 0.88 1.43 ± 0.85 1.54 ± 0.70 0.711 0.934 0.924
Total cholesterol (mmol/L) 5.18 ± 1.27 5.43 ± 1.31 5.03 ± 0.85 5.01 ± 0.72 0.966 0.292 0.638
HDL-c (mmol/L) 1.44 ± 0.25 1.46 ± 0.41 1.48 ± 0.36 1.42 ± 0.30 0.632 0.747 0.634
LDL-c (mmol/L) 3.15 ± 1.13 3.34 ± 1.09 3.02 ± 0.62 2.96 ± 0.63 0.862 0.249 0.599

Values are presented as mean ± SD. HP-L high polyunsaturated fat diet at lunch, HP-D high polyunsaturated fat diet at dinner, HM-L high monounsaturated fat diet at lunch, HM-D high monounsaturated fat diet at dinner, BMI body mass index, AUCglucose area under the curve of glucose, HbA1c glycated hemoglobin A1c, AUCinsulin area under the curve of insulin, HDL-c high-density lipoprotein cholesterol, LDL-c low-density lipoprotein cholesterol. Analysis was done using three-way repeated measures ANOVA (two-sided) followed by post hoc Bonferroni test. *P < 0.05.