Table 2.
Demographics and clinical characteristics of the study cohort
| Benign | Precancerous | Early-stage HNSCC | Advanced HNSCC | |
|---|---|---|---|---|
| N = 56 | N = 29 | N = 39 | N = 48 | |
| Agea | 48 ± 12.93 | 54 ± 13.45 | 64 ± 8.70 | 63 ± 12.05 |
| Sex | ||||
| Female | 27 | 6 | 3 | 9 |
| Male | 29 | 23 | 36 | 39 |
| Smoking status | ||||
| Nonsmokers | 31 | 9 | 11 | 13 |
| Smokers | 22 | 15 | 22 | 28 |
| Former smoker | 2 | 5 | 6 | 6 |
| Unknown or Not Applicable | 1 | 0 | 0 | 1 |
| Drinking status | ||||
| Nondrinkers | 53 | 23 | 25 | 33 |
| Drinkers | 1 | 5 | 11 | 9 |
| Former drinkers | 1 | 1 | 3 | 5 |
| Unknown or Not Applicable | 1 | 0 | 0 | 1 |
| T stage | ||||
| Tis | 0 | 0 | 4 | 0 |
| T1 | 0 | 0 | 15 | 6 |
| T2 | 0 | 0 | 20 | 2 |
| T3 | 0 | 0 | 0 | 21 |
| T4 | 0 | 0 | 0 | 19 |
| Unknown or Not Applicable | 56 | 29 | 0 | 0 |
| N stage | ||||
| N0 | 0 | 0 | 39 | 24 |
| N1 | 0 | 0 | 0 | 11 |
| N2 | 0 | 0 | 0 | 12 |
| N3 | 0 | 0 | 0 | 1 |
| Unknown or Not Applicable | 56 | 29 | 0 | 0 |
| M stage | ||||
| M0 | 0 | 0 | 39 | 47 |
| M1 | 0 | 0 | 0 | 1 |
| Unknown or Not Applicable | 56 | 29 | 0 | 0 |
| TNM stage | ||||
| 0 | 0 | 0 | 4 | 0 |
| I | 0 | 0 | 15 | 0 |
| II | 0 | 0 | 20 | 0 |
| III | 0 | 0 | 0 | 26 |
| IV | 0 | 0 | 0 | 22 |
| Unknown or Not Applicable | 56 | 29 | 0 | 0 |
| p16 IHC staining | ||||
| No staining | 0 | 2 | 28 | 23 |
| Faint | 0 | 0 | 2 | 6 |
| Moderate | 0 | 1 | 6 | 9 |
| Intense | 0 | 0 | 1 | 2 |
| Unknown or Not Applicable | 56 | 26 | 1 | 8 |
| Ki67 IHC staining | ||||
| Present | 0 | 3 | 36 | 40 |
| Unknown or Not Applicable | 56 | 26 | 3 | 8 |
aAge is presented as mean ± SD.