REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
Anti-Mouse CD25+ PE	BioGems	Cat# 07312-60
Anti-Mouse CD3+ BG Violet 450	BioGems	Cat# 05121-25
Anti-Mouse CD4+ BG Violet 500	BioGems	Cat# 06122-45
Anti-Mouse CD8+ FITC	BioGems	Cat# 10112-50
Anti-Mouse/Rat FOXP3 APC	BioGems	Cat# 83422-80
HRP-labelled Goat Anti-Rabbit IgG	Beyotime Biotechnology	Cat# A0208, RRID:AB_2892644
Mouse anti-SREBP1 antibody	Abcam	Cat# ab3259, RRID: AB_1851381
Rabbit anti-Akt antibody	Abcam	Cat# 9272, RRID:AB_329827
Rabbit anti-AMPK antibody	Cell Signaling Technology	Cat# 2532, RRID:AB_330331
Rabbit anti-GADPH antibody	Abcam	Cat# 2118, RRID:AB_561053
Rabbit anti-p-Akt (Ser473) antibody	Cell Signaling Technology	Cat# 9271, RRID:AB_329825
Rabbit anti-p-AMPK (Thr172) antibody	Cell Signaling Technology	Cat# 2535, RRID:AB_331250
Rabbit anti-PI3K antibody	Abcam	Cat# ab191606, RRID:AB_2891324
Rabbit anti-PPARγ (81B8) antibody	Cell Signaling Technology	Cat# 2443, RRID:AB_823598
Rabbit anti-p-PI3K (Tyr458) antibody	Cell Signaling Technology	Cat# 4228, RRID:AB_659940
Chemical, peptides, and recombinant proteins
A83-01	Biogems	Cat# 9094360
Advanced DMEM/F12	Gibco	Cat# 12634-010
B27	Gibco	Cat# 17504-001
Bovine serum albumin	Sigma	Cat# A9418
Cell recovery solution	Corning	Cat# 354253
Human [leu15]-Gastrin I	Sigma-Aldrich	Cat# G9145
Mogengel Matrix	Mogengel	Cat# 082703
N-acetyl L-cysteine	Sigma-Aldrich	Cat# A9165
Nicotinamide	Sigma-Aldrich	Cat# N0636
Noggin	MCE	Cat# HY-P70558
Prostaglandin E2	MCE	Cat# HY-101952
R-spondin-1	MCE	Cat# HY-P7114
SB 202190	MCE	Cat# HY-10295
Wnt3a	MCE	Cat# HY-P70453C
Deposited data
Raw data of Proteome Data	This paper	Mendeley Data, https://doi.org/10.17632/wwgdbwrbxr.1
Raw data of Metabolome Data	This paper	Mendeley Data, https://doi.org/10.17632/r49ggwxbvp.1
Raw data of ITS Data	This paper	Mendeley Data, https://doi.org/10.17632/y75322dtzy.1
Raw data of Western Blot Data	This paper	Mendeley Data, https://doi.org/10.17632/3fzfd2npw8.1
Critical commercial assays
All-in-one RT SuperMix Perfect for qPCR	Vazyme Biotech	Cat# R333
Cell/Tissue Total RNA Isolation Kit	Vazyme Biotech	Cat# RC112
Spin Column Animal Total RNA Purification Kit	Sangon Biotech	Cat# B518651
SYBR qPCR Master Mix	Vazyme Biotech	Cat# Q712
Experimental models: Organisms/strains
C57BL/6J (male)	GemPharmatch	Strain NO.N000013
C57BL/6J ApoE−/−(male)	GemPharmatch	Strain NO.T001458
Software and algorithms
DAVID	DAVID Team	RRID:SCR_001881
FLowJo v10.8	Tree Star	RRID: SCR_008520
GraphPad Prism 7.0	GraphPad software	RRID: SCR_002798
ImageJ	NIH	RRID: SCR_003070
Metaboanalyst 5.0	NIH-Canada Research	RRID: SCR_015539
Metascape	NIH-metascape.team	RRID:SCR_016620
RStudio	RStudio, Inc	RRID:SCR_000432