Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Structure‐activity relationships among aryl vinyl sulfones. Electron‐withdrawing groups on sulfur (R1) increase rate of inactivation. Aromatic and heteroaromatic rings (R2 in Scheme 2) are well tolerated at the β‐carbon, as is the alanyl group. Quinolines and pyridines with multiple regiochemical orientations of the nitrogen versus the vinyl group. H‐bond acceptors (R3) para with respect to the vinyl group improve binding.
