Table 2.

Differentially expressed genes in abdominal subcutaneous adipose tissue biopsies after lifestyle and GLP-1RA treatment.

Gene	p value	Adjusted p value	LogFC	Gene description
Differentially expressed genes (baseline vs. 12 weeks of GLP-1RA treatment)
HTRA2	8.62 × 10-7	0.017	2.08	HtrA serine peptidase 2
CPA6	3.95 × 10-6	0.031	2.30	Carboxypeptidase A6
MDGA1	4.99 × 10-6	0.031	2.01	MAM domain containing glycosylphosphatidylinositol anchor 1
CDC42EP1	6.48 × 10-6	0.031	2.63	CDC42 effector protein 1
LINC00881	1.17 × 10-5	0.036	1.80	Long intergenic non-protein coding RNA 881
ZFP62	1.46 × 10-5	0.036	2.17	ZFP62 zinc finger protein
KRT73-AS1	1.54 × 10-5	0.036	1.79	KRT73 antisense RNA 1
RALGPS2	1.61 × 10-5	0.036	2.04	Ral GEF with PH domain and SH3 binding motif 2
SP8	1.70 × 10-5	0.036	1.86	Sp8 transcription factor
APCS	2.34 × 10-5	0.045	1.72	Amyloid P component, serum
SVBP	2.59 × 10-5	0.045	2.09	Small vasohibin binding protein
PTCD2	3.07 × 10-5	0.049	2.32	Pentatricopeptide repeat domain 2
SIGLEC7	3.31 × 10-5	0.049	1.89	Sialic acid-binding Ig like lectin 7
SYCP1	3.65 × 10-5	0.050	2.08	Synaptonemal complex protein 1
Differentially expressed genes (GLP-1RA vs. lifestyle 12 weeks after treatment withdrawal)
GAB4	1.10 × 10-7	0.0013	2.31	GRB2 associated binding protein family member 4
CAMK2B	1.33 × 10-7	0.013	3.01	Calcium/calmodulin-dependent protein kinase II beta
VWDE	1.32 × 10-6	0.0084	2.32	von Willebrand factor D and EGF domains
KLHL28	0.000005	0.026	2.20	Kelch like family member 28