Table 3.

First Key Secondary Endpoint: SPID48 Compared to HB/APAP

	Abdominoplasty		Bunionectomy
	Suzetrigine N = 447	HB/APAP N = 448	Suzetrigine N = 426	HB/APAP N = 431
Prespecified analysis with rescue imputation (imputed)
LS mean ± SE	118.4 ± 4.3	111.8 ± 4.3	99.9 ± 4.5	120.1 ± 4.5
LS mean difference from HB/APAP	6.6	—	–20.2	—
95% CI	(–5.4 to 18.7)	—	(–32.7 to –7.7)	—
P value vs. HB/APAP	0.2781	—	0.0016	—
Post hoc analysis without rescue imputation (as treated)
LS mean ± SE	153.0 ± 4.5	141.0 ± 4.5	128.8 ± 4.7	140.6 ± 4.7
LS mean difference from HB/APAP	12.0	—	–11.8	—
95% CI	(–0.5 to 24.4)	—	(–24.8 to 1.2)	—
Nominal P value vs. HB/APAP*	0.0595	—	0.0752	—

Table includes participants who were randomized and received at least one dose of study drug. Participants were analyzed according to their randomized treatment.

^*Analyses for SPID48 compared to HB/APAP without rescue imputation are post hoc; therefore, P values are nominal.

HB/APAP, hydrocodone bitartrate/acetaminophen; LS mean, least squares mean; N, number of participants in the analysis set; SE, standard error; SPID48, time‑weighted sum of the pain intensity difference as recorded on the numeric pain rating scale from 0 to 48 h.