Table 5.

Post Hoc Subgroup Analysis of Time to 2-Point or Greater Reduction in NPRS from Baseline Compared to Placebo in Participants with Baseline NPRS 6 or Greater

	Abdominoplasty		Bunionectomy
	Suzetrigine N = 363	Placebo N = 198	Suzetrigine N = 285	Placebo N = 159
NPRS, mean ± SD	7.9 ± 1.3	7.9 ± 1.4	7.7 ± 1.3	7.6 ± 1.3
With rescue imputation (imputed)
Median time, min	115	480	115	480
95% CI	(90–179)	(476–481)	(87–475)	(180–716)
Nominal P value vs. placebo* (log-rank test)	< 0.0001	—	0.0008	—
Without rescue imputation (as treated)
Median time, min	90	180	95	175
95% CI	(86–115)	(124–182)	(86–123)	(90–235)
Nominal P value vs. placebo* (log-rank test)	< 0.0001	—	0.0128	—

Table includes participants who were randomized and received at least one dose of study drug. Participants were analyzed according to their randomized treatment.

^*These are post hoc analyses; therefore, P values are nominal.

N, number of participants in the analysis set; NPRS, numeric pain rating scale.