Table 3.
Novel loci in the multitrait meta-analysis between SCZ and risk factors in East Asians
| Risk Factors | SNP | CHR | BP | A1 | A2 | Trait1 | Trait2 | MTAG | Genes | Annotation | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Beta | P Value | Beta | P Value | Beta | P Value | ||||||||
| HDL | rs11956411 | 5 | 140853856 | C | T | −0.097 | 1.08E-07 | −0.02 | 1.40E-03 | −0.035 | 2.77E-08 | PCDHGC3 | New |
| TCL | rs11956411 | 5 | 140853856 | T | C | 0.097 | 1.08E-07 | 0.005 | 1.00E-03 | 0.036 | 1.54E-08 | PCDHGC3 | New |
| Stable angina pectoris | rs2237079 | 5 | 140877905 | A | G | −0.085 | 1.24E-07 | 0.013 | 1.94E-03 | −0.033 | 4.65E-08 | PCDHGC3 | New |
| Antihypertensive use measurement | rs62297721 | 4 | 66504803 | A | G | 0.074 | 6.44E-08 | 0.019 | 4.81E-03 | 0.033 | 1.78E-08 | EPHA5 | New |
| Antithrombotic agent use measurement | rs117325001 | 8 | 26242272 | T | G | 0.074 | 6.62E-08 | 0.008 | 8.98E-03 | 0.033 | 2.49E-08 | BNIP3L | New |
| Aspirin use measurement | rs117325001 | 8 | 26242272 | T | G | 0.074 | 6.62E-08 | 0.008 | 9.52E-04 | 0.033 | 2.44E-08 | BNIP3L | New |
| Vasodilators used in cardiac diseases use measurement | rs61824368 | 1 | 179298809 | T | C | −0.075 | 1.19E-07 | 0.013 | 2.51E-03 | −0.033 | 3.26E-08 | SOAT1 | New |
Note: The sections labeled “Trait 1” and “Trait 2” display the statistical results from the original GWAS for the traits involved in the MTAG analysis, MTAG section of the table presents the MTAG results specific to Trait 1. Trait1, schizophrenia; Trait2, risk factors.