TABLE 3.
Analysis of genotypes and alleles at different loci in the control and migraine groups and subtypes.
| SNPs | Controls (n = 210) | Cases (n = 216) | P Case vs control | MA (n = 30) | P MA vs control | MO (n = 182) | P MO vs control | Family history (n = 107) | P History vs control | No family history (n = 105) | P No history vs control |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Rs1800629 | 0.553 | >0.999 | 0.627 | 0.882 | 0.881 | ||||||
| GG | 178 (84.8) | 180 (84.9) | 26 (86.7) | 154 (84.6) | 91 (85.0) | 89 (84.8) | |||||
| GA | 30 (14.3) | 32 (15.1) | 4 (13.3) | 28 (15.4) | 16 (15.0) | 16 (15.2) | |||||
| AA | 2 (1.0) | 0 | 0 | 0 | 0 | 0 | |||||
| G | 386 (91.9) | 376 (92.5) | 0.767 | 56 (93.3) | 0.898 | 336 (92.3) | 0.835 | 198 (92.5) | 0.785 | 194 (92.4) | 0.835 |
| A | 34 (8.1) | 32 (7.5) | 4 (6.7) | 28 (7.7) | 16 (7.5) | 16 (7.6) | |||||
| GA + AA/GG | 32/178 | 32/180 | 0.967 | 4/26 | >0.999 | 28/154 | 0.968 | 16/91 | 0.947 | 16/89 | >0.999 |
| Rs1799724 | 0.550 | 0.384 | 0.808 | 0.890 | 0.394 | ||||||
| CC | 157 (74.8) | 166 (78.3) | 26 (86.7) | 140 (76.9) | 83 (77.6) | 83 (79.0) | |||||
| CT | 49 (23.3) | 44 (20.8) | 4 (13.3) | 40 (22.0) | 22 (20.6) | 22 (20.6) | |||||
| TT | 4 (1.9) | 2 (0.9) | 0 | 2 (1.1) | 2 (1.9) | 0 | |||||
| C | 363 (86.4) | 376 (88.7) | 0.322 | 56 (93.3) | 0.133 | 320 (87.9) | 0.536 | 188 (87.9) | 0.616 | 188 (89.5) | 0.269 |
| T | 57 (13.6) | 48 (11.3) | 4 (6.7) | 44 (12.1) | 26 (12.1) | 22 (10.5) | |||||
| CT + TT/CC | 53/157 | 46/166 | 0.391 | 4/26 | 0.152 | 42/140 | 0.618 | 24/83 | 0.581 | 22/83 | 0.400 |
| Rs361525 | 0.922 | 0.337 | 0.910 | >0.999 | 0.759 | ||||||
| GG | 196 (93.3) | 198 (93.4) | 26 (86.7) | 172 (94.5) | 101 (94.4) | 97 (92.4) | |||||
| GA | 13 (6.2) | 14 (6.6) | 4 (13.3) | 10 (5.5) | 6 (5.6) | 8 (7.6) | |||||
| AA | 1 (0.5) | 0 | 0 | 0 | 0 | 0 | |||||
| G | 405 (96.4) | 410 (96.7) | 0.830 | 56 (93.3) | 0.426 | 354 (97.3) | 0.512 | 208 (97.2) | 0.610 | 202 (96.2) | 0.881 |
| A | 15 (3.6) | 14 (3.3) | 4 (6.7) | 10 (2.7) | 6 (2.8) | 8 (3.8) | |||||
| GA + AA/GG | 14/196 | 14/198 | 0.979 | 4/26 | 0.354 | 10/172 | 0.629 | 6/101 | 0.714 | 8/97 | 0.755 |
| Rs1143634 | 0.038* | 0.398 | 0.060 | 0.050* | 0.200 | ||||||
| CC | 189 (90.0) | 202 (95.3) | 29 (96.7) | 173 (95.1) | 103 (96.3) | 99 (94.3) | |||||
| CT | 21 (10.0) | 10 (4.7) | 1 (3.3) | 9 (4.9) | 4 (3.7) | 6 (5.7) | |||||
| TT | 0 | 0 | 0 | 0 | 0 | 0 | |||||
| C | 399 (95.0) | 414 (97.6) | 0.041* | 59 (98.3) | 0.409 | 355 (94.9) | 0.959 | 210 (98.1) | 0.055 | 204 (97.1) | 0.211 |
| T | 21 (5.0) | 10 (2.4) | 1 (1.7) | 19 (5.1) | 4 (1.9) | 6 (2.9) | |||||
| CT + TT/CC | 21/189 | 10/202 | 0.038* | 1/29 | 0.398 | 9/173 | 0.060 | 4/103 | 0.050* | 6/99 | 0.200 |
| Rs419598 | 0.931 | >0.999 | >0.999 | 0.697 | 0.667 | ||||||
| TT | 191 (91.0) | 194 (91.5) | 28 (93.3) | 166 (91.2) | 95 (88.8) | 99 (94.3) | |||||
| CT | 18 (8.6) | 18 (8.5) | 2 (6.7) | 16 (8.8) | 12 (11.2) | 6 (5.7) | |||||
| CC | 1 (0.5) | 0 | 0 | 0 | 0 | 0 | |||||
| T | 400 (95.2) | 406 (95.8) | 0.717 | 58 (96.7) | 0.869 | 348 (95.6) | 0.807 | 202 (94.4) | 0.646 | 204 (97.1) | 0.257 |
| C | 20 (4.8) | 18 (4.2) | 2 (3.3) | 16 (4.4) | 12 (5.6) | 6 (2.9) | |||||
| CT + CC/TT | 19/191 | 18/194 | 0.840 | 2/28 | 0.931 | 16/166 | 0.929 | 12/95 | 0.539 | 6/90 | 0.302 |
MA: migraine with aura; MO: migraine without aura.