Table 2.
MIC, MBC and MFC of naturally xanthanolides and semisynthetic derivatives 3, 3′, 7 and 8 (mg/mL)
| Compounds | Sa | MRSA | Ca | Ct | Cn | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| MIC | MBC | MIC | MBC | MIC | MFC | MIC | MFC | MIC | MFC | |
| 8-epi-xanthatin | 0.50–0.25 | 1.0–0.5 | 0.25 | 0.50 | 0.25–0.125 | 0.50 | 0.25 | 0.50 | 0.06–0.03 | 0.125 |
| Xanthatin | 0.50–0.25 | 0.5 | 0.125 | 0.25 | 0.25–0.125 | 0.25–0.125 | 0.25–0.125 | 0.25 | 0.06–0.03 | 0.125 |
| Isoxanthanol | 0.25–0.125 | 1.0 | 0.25–0.125 | 0.50 | 1 | > 1 | NT | NT | NT | NT |
| 8-epi-isoxanthanol | 0.125 | 1.0 | 0.125 | 0.25 | > 1 | NT | NT | NT | NT | NT |
| 3 | 0.25 | 1.0 | 0.125 | 0.5 | 1.0 | > 1 | > 1 | NT | > 1 | NT |
| 3′ | 0.25 | 1.0 | 0.25–0.125 | 1.0 | 1.0 | 1.0 | 1.0 | 1.0 | 0.50 | 0.50 |
| 7 | 0.50 | > 1.0 | 0.50 | 1.0 | > 1 | NT | NT | NT | NT | NT |
| 8 | 0.50 | > 1.0 | 0.50 | > 1.0 | 0.125 | 0.125 | 0.25–0.125 | 0.50 | 0.06–0.03 | 0.125 |
| Ampicillin | 1.6 × 10–4 | NT | 3 × 10–3 | NT | NT | NT | NT | NT | NT | NT |
| Ketoconazole | NT | NT | NT | NT | 3.8 × 10–3 | NT | 3.4 × 10–3 | NT | 6 × 10–4 | NT |
NT: Not tested