Table 2.
STING inhibitors.
| Medicine | Structure | Pharmacological mechanisms | Models | Reference |
|---|---|---|---|---|
| Nitrofuran derivatives |
|
Binds to the Cys91 residue on the STING protein, inhibiting its palmitoylation | Mice: Trex1−/− mice; Cell: BMDMs, HEK293T cell |
(26, 32) |
| H-151 |
|
Selective covalent antagonist of STING, reduce phosphorylation of TBK1 and suppress palmitoylation of human STING | Mice: C57BL/6J mice; Cell: BMDMs |
(32, 129) |
| NO2-OA |
|
Targeting the palmitoylation site | Mice: Nos2−/− mice, STING-KO mice; Cell: RAW264.7, BMMs, THP-1 |
(132) |
| NO2-cLA |
|
Targeting the palmitoylation site | Mice: Nos2−/− mice, STING-KO mice; Cell: RAW264.7, BMMs, THP-1 |
(132) |
| Astin C |
|
Binds to the C-terminal activation pocket of STING and reduce the recruitment of IRF3 | Mice: Trex1−/− mice; Cell: RAW264.7, MEFs, hPBMCs, HEK cell |
(134) |
| Compound 18 |
|
Inhibits STING by blocking the CDN binding domain | Cell: THP1 cell | (135) |