TABLE 1.

Summary of the effects of TAAR1 agonists on stress-related disorders in animals.

TAAR1 agonists	Psychiatric disorders	Behaviors	Effects	References
RO5166017	Anxiety	Stress-induced hyperthermia	Attenuated	Revel et al. (2011)
	PTSD	Stress-enhanced fear learning	Attenuated	Peng et al. (2024)
RO5256390	Anxiety	Elevated plus maze Open field test	No change Decreased time spent in central zone	Raony et al. (2022)
	Depression	Forced swim test A differential reinforcement for low-rate paradigm	No change Increased the number of reinforcers obtained but decreased the response rate	Revel et al. (2013)
RO5263397	Anxiety	Stress-induced hyperthermia Nicotine withdrawal-induced anxiety	Attenuated Attenuated	Revel et al. (2011), Zhang et al. (2021), Wu et al. (2022)
		Elevated plus maze	No change
		Chronic stress-induced anxiety	No change
	PTSD	Stress-enhanced fear learning Single prolonged stress-induced extinction impairment	Attenuated Attenuated extinction impairment	Peng et al. (2024)
	Depression	Forced swim test A differential reinforcement for low-rate paradigm Chronic stress-induced social avoidance	Attenuated immorbility Increased the number of reinforcers obtained but decreased the response rate Reversed	Revel et al. (2013), Zhang et al. (2021), Zhang et al. (2024)
RO5203648	Anxiety	Stress-induced hyperthermia	Attenuated	Revel et al. (2011)
	Depression	Forced swim test Tail suspension test A differential reinforcement for low-rate paradigm	Attenuated immorbility Attenuated immorbility Prolonged the inter-response time and a reduction in the response rate	Revel et al. (2012)
SEP363856	Depression	Forced swim test Tail suspension test Chronic unpredicted mild stress (CUMS)	Attenuated immorbility Attenuated immorbility Attenuated CUMS-induced reductions in sucrose preference	Ren et al. (2022), Dedic et al. (2019), Li et al. (2024)
PCC0105004	Bipolar disorders	Ouabain-induced biplolar-like behaviors	Attenuated	Yu et al. (2024)