TABLE 5.
Plasma pharmacokinetic parameters of cinnamic acid after oral administration of CR-PLR granules and CR granules in the model group of rats (‾x ± SD, n = 6).
| Parameters | CR-PLR | CR |
|---|---|---|
| Cmax (μg/L) | 723.28 ± 115.24 | 533.42 ± 70.01 |
| Tmax (min) | 10.00 | 15.00 ± 5.00 |
| t1/2 (min) | 329.42 ± 48.07 | 365.65 ± 92.99 |
| AUC0-12 (μg/L·min) | 232,832.48 ± 47,399.51 | 143,032.11 ± 10,673.33 |
| AUC0-∞ (μg/L·min) | 292,142.24 ± 44,006.00 | 188,352.51 ± 6,196.84 |
| MRT0-t (min) | 271.13 ± 7.89 | 276.78 ± 19.00 |