Table 3.

Univariate and multivariate logistic regression analysis.

Parameter	UV OR (95% CI)	UV p	MV OR (95% CI)	MV p*
Age	1.51 (0.90–2.53)	0.118
Gender	0.62 (0.37–1.04)	0.069
Weight	1.67 (0.98–2.83)	0.059
Tumor origin	0.43 (0.25–0.75)	0.003	0.56 (0.27–1.13)	0.104
Steroid	0.42 (0.17–1.04)	0.061
Dehydrant	0.38 (0.14–1.03)	0.058
Radiotherapy	0.58 (0.33–1.02)	0.059
Operation	0.53 (0.30–0.96)	0.036	0.62 (0.28–1.35)	0.225
Electrolyte disorder	1.65 (0.94–2.88)	0.080
New-onset hypertension	0.56 (0.29–1.08)	0.083
BEV dose	1.07 (0.99–1.17)	0.103
BEV interval	0.58 (0.34–1.00)	0.052
BEV frequency	0.85 (0.72–1.00)	0.058
Tumor location	0.68 (0.24–1.87)	0.450
Maximum tumor diameter	0.57 (0.32–1.00)	0.048	0.97 (0.36–2.58)	0.945
Tumor volume	0.96 (0.92–1.00)	0.053
Edema volume	1.13 (1.10–1.16)	< 0.001	1.09 (1.04–1.13)	< 0.001*
Edema index	3.63 (2.48–5.33)	< 0.001	1.87 (1.12–3.12)	0.017*

An asterisk (*) indicates a statistically significant P value of less than 0.05.

UV, Univariable; MV, Multivariable; CI, Confidence Interval; OR, Odds Ratio; BEV, Bevacizumab.