Table 5.
Stratification analysis for the associations of YTHDF1 and YTHDF3 gene polymorphisms with neuroblastoma risk in children from Jiangsu Province
| Variables |
YTHDF1 rs6011668 (cases/controls) |
AOR (95% CI) a | P a |
YTHDF3 rs7464 (cases/controls) |
AOR (95% CI) a | P a | ||
|---|---|---|---|---|---|---|---|---|
| CC | CT/TT | AA | AG/GG | |||||
| Age, month | ||||||||
| ≤ 18 | 96/99 | 43/40 | 1.11 (0.66–1.86) | 0.689 | 77/77 | 62/62 | 1.00 (0.62–1.60) | 0.998 |
| > 18 | 186/253 | 77/81 | 1.29 (0.90–1.86) | 0.167 | 128/187 | 135/147 | 1.34 (0.97–1.86) | 0.075 |
| Gender | ||||||||
| Females | 130/169 | 61/56 | 1.42 (0.92–2.18) | 0.112 | 100/130 | 91/95 | 1.25 (0.85–1.84) | 0.268 |
| Males | 152/183 | 59/65 | 1.09 (0.72–1.65) | 0.677 | 105/134 | 106/114 | 1.19 (0.82–1.71) | 0.365 |
| Sites of origin | ||||||||
| Adrenal gland | 69/352 | 24/121 | 1.01 (0.61–1.68) | 0.963 | 46/264 | 47/209 | 1.28 (0.82-2.00) | 0.274 |
| Retroperitoneal | 113/352 | 54/121 | 1.39 (0.95–2.04) | 0.093 | 91/264 | 76/209 | 1.06 (0.74–1.51) | 0.759 |
| Mediastinum | 87/352 | 33/121 | 1.10 (0.70–1.73) | 0.668 | 55/264 | 65/209 | 1.49 (1.00-2.23) | 0.051 |
| Others | 11/352 | 7/121 | 1.84 (0.70–4.86) | 0.219 | 10/264 | 8/209 | 1.02 (0.40–2.64) | 0.964 |
| Clinical stages | ||||||||
| I + II + 4s | 125/352 | 48/121 | 1.12 (0.76–1.66) | 0.572 | 96/264 | 77/209 | 1.02 (0.71–1.44) | 0.932 |
| III + IV | 109/352 | 54/121 | 1.44 (0.98–2.12) | 0.063 | 79/264 | 84/209 | 1.34 (0.93–1.91) | 0.113 |
AOR, adjusted odds ratio; CI, confidence interval
a Adjusted for age and gender, omitting the correspondence factor