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. 2025 Feb 7;36(4):609–625. doi: 10.1007/s00198-025-07393-5

Table 4.

GRADE assessment on the meta-analysis of combined milk-derived protein and exercise interventions compared to exercise alone on bone mineral content (kg)

Certainty assessment Summary of findings
Participants (studies) follow-up Risk of bias Inconsistency Indirectness Imprecision Publication bias Overall certainty of evidence Participants Anticipated absolute effects
With exercise With milk protein  +  exercise Risk difference with protein  +  exercise
142 (4 RCTs) Seriousa Not serious Not serious Seriousb None ⨁⨁◯◯ Low 72 71 MD 0.01 kg higher (0.01 lower to 0.03 higher)

CI confidence interval, MD weighted mean difference

aAll studies were rated as “some concerns”

bThe 95% confidence interval of the pooled effect crossed the line of no effect