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. 2025 Apr 23;64(5):757–767. doi: 10.1007/s40262-025-01506-3
Phase 2 studies showed that the dosing regimen for fepixnebart (LY3016859), a new drug being developed to treat various types of chronic pain, was effective in engaging its target, with a high percentage of subjects showing strong engagement.
Epiregulin, a ligand for EGFR, is a promising target for treating chronic pain due to its role in persistent EGFR pathway activation.