Table 2.
Univariate and multivariate Cox hazards analysis for OS in DLBCL.
| Vb Variables | Univariable | Multivariable | ||
|---|---|---|---|---|
| HR (95% CI) | P value | HR (95% CI) | P value | |
| Sex | ||||
| Female | reference | |||
| Male | 1.45 (0.81-2.60) | 0.208 | ||
| Age | ||||
| ≤60 | reference | reference | ||
| >60 | 3.29 (1.77-6.12) | <0.001 | 3.50 (1.84-6.67) | <0.001 |
| BMI | 0.96 (0.87-1.06) | 0.393 | ||
| NEUT (*109/L) | 1.02 (0.98-1.06) | 0.303 | ||
| LYM (*109/L) | 1.14 (0.71-1.80) | 0.591 | ||
| HB (g/L) | 0.99 (0.98-1.00) | 0.053 | ||
| PLT (*109/L) | 1.00 (1.00-1.00) | 0.569 | ||
| ALB (g/L) | 0.95 (0.89-1.02) | 0.163 | ||
| FBG (mmol/L) | 1.07 (0.97-1.18) | 0.162 | ||
| TG (mmol/L) | 1.10 (0.85-1.41) | 0.472 | ||
| TC (mmol/L) | 0.57 (0.41-0.79) | <0.001 | 0.46 (0.20-1.08) | 0.074 |
| HDL (mmol/L) | 0.41 (0.19-0.89) | 0.024 | 2.14 (0.84-5.47) | 0.112 |
| LDL (mmol/L) | 0.51 (0.32-0.82) | 0.005 | 1.32 (0.48-3.58) | 0.590 |
| ApoA (g/L) | 0.62 (0.30-1.30) | 0.208 | ||
| ApoB (g/L) | 0.98 (0.28-3.43) | 0.973 | ||
| LDH | ||||
| Low | reference | reference | ||
| High | 3.08 (1.74-5.45) | <0.001 | 2.04 (1.08-3.86) | 0.028 |
| ECOG PS | ||||
| Low | reference | reference | ||
| High | 4.53 (2.31-8.91) | <0.001 | 3.16 (1.48-6.72) | 0.003 |
| B symptoms | ||||
| No | reference | reference | ||
| Yes | 2.65 (1.44-4.89) | 0.002 | 1.51 (0.77-2.98) | 0.230 |
| Extranodal site | ||||
| 0 | reference | reference | ||
| 1 | 3.03 (1.72-5.35) | <0.001 | 1.41 (0.72-2.74) | 0.318 |
| Hans | ||||
| Non-GCB | reference | |||
| GCB | 1.75 (1.00-3.06) | 0.052 | ||
| Ann Arbor stage | ||||
| Low | reference | reference | ||
| High | 4.43 (2.15-9.14) | <0.001 | 2.55 (1.12-5.79) | 0.026 |
| Ki 67 | 1.08 (0.14-8.46) | 0.939 | ||
| NLR | 1.00 (0.99-1.02) | 0.459 | ||
| PLR | 1.00 (1.00-1.00) | 0.588 | ||
| SII | 1.00 (1.00-1.00) | 0.378 | ||
| TyG index | ||||
| Low | reference | reference | ||
| High | 2.22 (1.22-4.03) | 0.009 | 2.57 (1.25-5.31) | 0.011 |
BMI, body mass index; NEUT, neutrophil count; LYM, lymphocyte count; HB, hemoglobin; PLT, platelet count; ALB, albumin; ECOG PS, eastern cooperative oncology group performance status; GCB, germinal center B-cell; IPI, international prognostic index; LDH, lactate dehydrogenase; FBG, fasting blood glucose; TG, triacylglycerol; TC, total cholesterol; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; ApoA, apolipoprotein A; ApoB, apolipoprotein B; TyG index, triglyceride glucose index; NLR, neutrophil to lymphocyte ratio; PLR, platelet to lymphocyte ratio; SII, systemic immune inflammation index.