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. 2025 Apr 28;12:1589907. doi: 10.3389/fnut.2025.1589907

Table 2.

Primary and secondary outcomes between the zinc deficiency group and the control group.

Outcome ZD group (n = 4,145) Control group (n = 4,145) HR (95% CI) P value E-value (95% LCL)
Events (n) Incidence rate
per 100 person-years
Events (n) Incidence rate
per 100 person-years
Primary outcome
All-cause mortality 558 13.47 405 9.78 1.46 (1.29, 1.66) <0.001 2.28 (1.90)
MACEs 658 15.89 481 11.61 1.46 (1.30, 1.64) <0.001 2.28 (1.92)
MAKEs 652 15.74 460 11.11 1.51 (1.34, 1.70) <0.001 2.39 (2.01)
Secondary outcomes
All-cause hospitalization 2,102 50.75 1,894 45.72 1.24 (1.16, 1.32) <0.001 1.59 (1.45)

MACE, major adverse cardiovascular event; MAKE, major adverse kidney event; ZD, zinc deficiency.