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. 2025 Apr 29;16(5):887–895. doi: 10.1021/acsmedchemlett.5c00147

Table 2. Effect of C7 Substitution on Potency and In Vitro ADME Properties.

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a

Data are the geometric mean of two independent experiments (n = 2) unless otherwise specified. Assay details reported in Supporting Information.

b

Permeability (Papp × 10–6 cm/s) as measured in PAMPA assay.

c

Half-life of compound incubated with rat liver microsomes (RLM).