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. 2025 Apr 29;16(5):887–895. doi: 10.1021/acsmedchemlett.5c00147

Table 3. Effect of Central Ring on Potency, hERG, and In Vitro ADME Properties.

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a

Data are the geometric mean of two independent experiments (n = 2) unless otherwise specified. Assay details reported in Supporting Information.

b

Permeability (Papp × 10–6 cm/s) as measured in PAMPA assay.

d

Half-life of compound incubated with rat (R), mouse (M), or human (H) liver microsomes (LM).

e

Data are from a single experiment (n = 1).