Table 5. Cellular Potencies of Key Compounds.
| 27 | 30 | 36 | |
|---|---|---|---|
| NanoBRET IRAK4 IC50 (nM)a | <0.5 | <0.5 | 1 |
| NanoBRET FLT3 IC50 (nM)a | 0.8 | 0.8 | 71 |
| NanoBRET FLT3 (D835Y) IC50 (nM)a | <0.5 | N.D. | <0.5 |
| NF-κB (Pam3SCK4) IC50 (nM)b | 16 | 25 | 16 |
| NF-κB (IL1B) IC50 (nM)b | 25 | 35 | 17 |
| MOLM14 (D835Y) IC50 (nM)c | 15 | 18d | 20e |
| MOLM14 (F691L) IC50 (nM)b | 139 | 85 | 55f |
a
Data are the geometric mean of two independent experiments (n = 2).
b
Data are the geometric mean of two independent experiments (n = 2) unless otherwise specified.
c
Data are the geometric mean of three independent experiments (n = 3) unless otherwise specified.
d
Data are the geometric mean of four independent experiments (n = 4).
e
Data are the geometric mean of two independent experiments (n = 2).
f
Data are from a single experiment (n = 1).