Table 6. Off-Target Activities of Key Compounds.
| 27 | 30 | 36 | |
|---|---|---|---|
| hERG IC50 (μM)a | 6.7 | 5.1 | 20.5 |
| Nav1.5 IC50 (μM)a | >30 | >30 | >30 |
| Cav1.2 IC50 (μM)a | >30 | >30 | >30 |
| CYP3A4 IC50 (μM)a | >25 | >25 | >25b |
| CYP2C9 IC50 (μM)a | >25 | >25 | 4b |
| CYP2D6 IC50 (μM)a | 15 | 8 | 12b |
| CYP1A2 IC50 (μM)b | >25 | >25 | >25 |
| CYP2B6 IC50 (μM)b | >25 | >25 | >25 |
| CYP2C8 IC50 (μM)b | >25 | >25 | >25 |
| CYP2C19 IC50 (μM)b | >25 | >25 | >25 |
a
Data are the geometric mean of two independent experiments (n = 2) unless otherwise specified.
b
Data are from a single experiment (n = 1).