Table 4. Bio-evaluation of compounds 3a–3o and 4a–4k.
| Compound | IC50 (μM) | |
|---|---|---|
| MOLM-13 | MV4-11 | |
| 3a | 28.99 ± 7.07 | 44.17 ± 1.34 |
| 3b | 34.80 ± 3.47 | 32.05 ± 3.97 |
| 3d | 84.35 ± 8.19 | 92.52 ± 6.20 |
| 3e | 24.44 ± 9.96 | 32.28 ± 5.21 |
| 3h | 30.29 ± 1.98 | 87.34 ± 1.81 |
| 3i | 31.74 ± 3.13 | 87.75 ± 0.62 |
| 3l | 13.24 ± 0.41 | 10.63 ± 0.44 |
| 3m | 19.79 ± 1.57 | 19.91 ± 1.68 |
| 3n | 8.53 ± 0.34 | 9.73 ± 0.17 |
| 4a | 86.57 ± 5.43 | 43.82 ± 1.48 |
| 4b | 42.41 ± 4.38 | 30.80 ± 1.15 |
| 4c | 10.64 ± 0.40 | 41.79 ± 8.01 |
| 4e | 17.95 ± 0.86 | 8.19 ± 1.87 |
| 4f | 19.94 ± 1.06 | 18.69 ± 2.38 |
| 4g | 10.43 ± 0.37 | 13.54 ± 3.65 |
| 4i | 44.19 ± 3.97 | 72.58 ± 9.05 |
| 4j | 47.07 ± 5.95 | 84.39 ± 6.86 |
| Cabozantinib | 0.045 | 0.003 |